We have recently shown that chemotherapy with immunogenic cell death (ICD)-inducing agents can be advantageously combined with fasting regimens or caloric restriction mimetics (CRMs) to achieve superior tumor growth control via a T cell-dependent mechanism.Here, we show that the blockade of the CD11b-dependent extravasation of myeloid cells blocks
Abstract Introduction Summer alpine sports, including mountain biking, hiking and airborne pursuits, have experienced a recent surge in popularity.Accordingly, trauma associated with these activities has increased.There is a scarcity of literature exploring clinical aspects surrounding injuries.Specifically, no single article provides a general ove
Abstract Introduction Summer alpine sports, including mountain biking, hiking and airborne pursuits, have experienced a recent surge in popularity.Accordingly, trauma associated with these activities has increased.There is a scarcity of literature exploring clinical aspects surrounding injuries.Specifically, no single article provides a general ove
Background & objectives: Cysteine proteases (falcipains), a papain-family of enzymes of Plasmodium falciparum, are responsible for haemoglobin degradation and thus necessary for its survival during asexual life cycle phase inside the human red blood cells while remaining non-functional for the human body.Therefore, these can act as potential target
The microtopography associated with ice-wedge polygons governs many aspects of Arctic ecosystem, permafrost, and hydrologic dynamics from local to regional scales owing to the linkages between microtopography and the flow and storage of water, vegetation succession, and permafrost dynamics.Wide-spread ice-wedge degradation is transforming low-cente